Ghana’s pharmaceutical market is entering a pivotal phase. As demand for quality-assured medicines rises, so does demand for greater local and regional production. Upholding current Good Manufacturing Practices (cGMP) is central to this growth. This playbook is a tool for chief executive officers (CEOs), chief operating officers (COOs), and business leaders making critical strategic investment decisions. The playbook provides: A business-oriented roadmap for achieving and sustaining cGMP compliance Guidance on sequencing investments in people, systems, and facilities A structured framework for choosing between retrofit, brownfield, and greenfield facility strategies Practical insights from comparable African manufacturers